Appraising the roles of CBLL1 and the ubiquitin/proteasome system for flavivirus entry and replication.

@article{FernandezGarcia2011AppraisingTR,
  title={Appraising the roles of CBLL1 and the ubiquitin/proteasome system for flavivirus entry and replication.},
  author={Maria-Dolores Fernandez-Garcia and Laurent Meertens and Matteo Bonazzi and Pascale Cossart and Fernando Arenzana-Seisdedos and Ali Amara},
  journal={Journal of virology},
  year={2011},
  volume={85 6},
  pages={2980-9}
}
The ubiquitin ligase CBLL1 (also known as HAKAI) has been proposed to be a critical cellular factor exploited by West Nile virus (WNV) for productive infection. CBLL1 has emerged as a major hit in a recent RNA interference screen designed to identify cellular factors required for the early stages of the WNV life cycle. Follow-up experiments showed that HeLa cells knocked down for CBLL1 by a small interfering RNA (siRNA) failed to internalize WNV particles and resisted infection. Furthermore… CONTINUE READING
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