Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology.

@article{Zhang2016AppoptosinIW,
  title={Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology.},
  author={Chuanlun L. Zhang and Zhun Shi and Lingzhi Zhang and Zehua Zhou and Xiaoyuan Zheng and Guiying Liu and Guojun D Bu and Paul E. Fraser and Huaxi Xu and Yunwu Zhang},
  journal={Journal of cell science},
  year={2016},
  volume={129 5},
  pages={
          994-1002
        }
}
Mitochondrial morphology is regulated by fusion and fission machinery. Impaired mitochondria dynamics cause various diseases, including Alzheimer's disease. Appoptosin (encoded by SLC25A38) is a mitochondrial carrier protein that is located in the mitochondrial inner membrane. Appoptosin overexpression causes overproduction of reactive oxygen species (ROS) and caspase-dependent apoptosis, whereas appoptosin downregulation abolishes β-amyloid-induced mitochondrial fragmentation and neuronal… CONTINUE READING

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