Applying novel methods to assess clinical outcomes: insights from the TRILOGY ACS trial.

@article{Bakal2015ApplyingNM,
  title={Applying novel methods to assess clinical outcomes: insights from the TRILOGY ACS trial.},
  author={Jeffrey A. Bakal and Matthew T. Roe and E Magnus Ohman and Shaun G. Goodman and Keith A. A. Fox and Yinggan Zheng and Cynthia M. Westerhout and Judith S. Hochman and Yuliya V Lokhnygina and Eileen B. Brown and Paul Wayne Armstrong},
  journal={European heart journal},
  year={2015},
  volume={36 6},
  pages={385-92a}
}
AIMS Several methods provide new insights into understanding clinical trial composite endpoints, using both conventional and novel methods. The TRILOGY ACS trial is used as a contemporary example to prospectively compare these methods side by side. METHODS AND RESULTS The traditional time-to-first-event, Andersen-Gill recurrent events method, win ratio, and a weighted composite endpoint (WCE) are compared using the randomized, active-control TRILOGY ACS trial. This trial had a neutral result… CONTINUE READING
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