Applying genome-wide gene-based expression quantitative trait locus mapping to study population ancestry and pharmacogenetics

@inproceedings{Yang2013ApplyingGG,
  title={Applying genome-wide gene-based expression quantitative trait locus mapping to study population ancestry and pharmacogenetics},
  author={Hsin-Chou Yang and Chien-Wei Lin and Chia-Wei Chen and James J. Chen},
  booktitle={BMC Genomics},
  year={2013}
}
Gene-based analysis has become popular in genomic research because of its appealing biological and statistical properties compared with those of a single-locus analysis. However, only a few, if any, studies have discussed a mapping of expression quantitative trait loci (eQTL) in a gene-based framework. Neither study has discussed ancestry-informative eQTL nor investigated their roles in pharmacogenetics by integrating single nucleotide polymorphism (SNP)-based eQTL (s-eQTL) and gene-based eQTL… CONTINUE READING

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