Applying a low-flow CO2 removal device in severe acute hypercapnic respiratory failure.

Abstract

A novel and portable extracorporeal CO2-removal device was evaluated to provide additional gas transfer, auxiliary to standard therapy in severe acute hypercapnic respiratory failure. A dual-lumen catheter was inserted percutaneously in five subjects (mean age 55 ± 0.4 years) and, subsequently, connected to the CO2-removal device. The median duration on support was 45 hours (interquartile range 26-156), with a blood flow rate of approximately 500 mL/min. The mean PaCO2 decreased from 95.8 ± 21.9 mmHg to 63.9 ± 19.6 mmHg with the pH improving from 7.11 ± 0.1 to 7.26 ± 0.1 in the initial 4 hours of support. Three subjects were directly weaned from the CO2-removal device and mechanical ventilation, one subject was converted to ECMO and one subject died following withdrawal of support. No systemic bleeding or device complications were observed. Low-flow CO2 removal adjuvant to standard therapy was effective in steadily removing CO2, limiting the progression of acidosis in subjects with severe acute hypercapnic respiratory failure.

DOI: 10.1177/0267659115589401

Cite this paper

@article{Sharma2016ApplyingAL, title={Applying a low-flow CO2 removal device in severe acute hypercapnic respiratory failure.}, author={Ajay S Sharma and Patrick W. Weerwind and Uli Strauch and Arne van Belle and Jos G. Maessen and Emiel F. M. Wouters}, journal={Perfusion}, year={2016}, volume={31 2}, pages={149-55} }