Applying Physiologically Relevant Strains to Tenocytes in an In Vitro Cell Device Induces In Vivo Like Behaviors.

@article{Kim2016ApplyingPR,
  title={Applying Physiologically Relevant Strains to Tenocytes in an In Vitro Cell Device Induces In Vivo Like Behaviors.},
  author={Jung Joo Kim and David S Musson and Brya Grace Matthews and Jillian Cornish and Iain A. Anderson and Vickie B. Shim},
  journal={Journal of biomechanical engineering},
  year={2016},
  volume={138 12}
}
We have developed a novel cell stretching device (called Cell Gym) capable of applying physiologically relevant low magnitude strains to tenocytes on a collagen type I coated membrane. We validated our device thoroughly on two levels: (1) substrate strains, (2) cell level strains. Our cell level strain results showed that the applied stretches were transferred to cells accurately (∼90%). Our gene expression data showed that mechanically stimulated tenocytes (4%) expressed a lower level of COL I… CONTINUE READING
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