Applying ‘Sequential Windowed Acquisition of All Theoretical Fragment Ion Mass Spectra’ (SWATH) for systematic toxicological analysis with liquid chromatography-high-resolution tandem mass spectrometry

@article{Arnhard2015ApplyingW,
  title={Applying ‘Sequential Windowed Acquisition of All Theoretical Fragment Ion Mass Spectra’ (SWATH) for systematic toxicological analysis with liquid chromatography-high-resolution tandem mass spectrometry},
  author={Kathrin Arnhard and Anna Edith Gottschall and Florian Pitterl and Herbert Oberacher},
  journal={Analytical and Bioanalytical Chemistry},
  year={2015},
  volume={407},
  pages={405-414}
}
AbstractLiquid chromatography-tandem mass spectrometry (LC-MS/MS) has become an indispensable analytical technique in clinical and forensic toxicology for detection and identification of potentially toxic or harmful compounds. Particularly, non-target LC-MS/MS assays enable extensive and universal screening requested in systematic toxicological analysis. An integral part of the identification process is the generation of information-rich product ion spectra which can be searched against… CONTINUE READING
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