Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way.

@article{Wilson2006ApplicationsOT,
  title={Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way.},
  author={Rebecca M. Wilson and Samuel J Danishefsky},
  journal={Accounts of chemical research},
  year={2006},
  volume={39 8},
  pages={
          539-49
        }
}
The possibility for the application of organic synthesis to the discovery of new agents in combating neurodegenerative disorders is described. Our focus has been on agents derived from natural-product leads and natural products themselves prepared through total synthesis. Herein, we describe some of the chemistry as well as interesting observations made along the way.