Applications of saturation transfer difference NMR in biological systems.

  title={Applications of saturation transfer difference NMR in biological systems.},
  author={Anirban Bhunia and Surajit Bhattacharjya and Subhrangsu Chatterjee},
  journal={Drug discovery today},
  volume={17 9-10},
The method of saturation transfer difference (STD) nuclear magnetic resonance (NMR) is an indispensable NMR tool in drug discovery. It identifies binding epitope(s) at the atomic resolution of small molecule ligands (e.g. organic drugs, peptides and oligosaccharides), while interacting with their receptors, such as proteins and/or nucleic acids. The method is widely used to screen active drug molecules, simultaneously ranking them in a qualitative way. STD NMR is highly successful for a variety… CONTINUE READING


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