Applications of respiratory mass spectrometry to intensive care

  title={Applications of respiratory mass spectrometry to intensive care},
  author={John W.W. Gothard and C M Busst and Margaret A. Branthwaite and N. J. H. Davies and David M. Denison},
A monitoring and research system based on a respiratory mass spectrometer controlled by a microprocessor has been installed in a paediatric intensive care unit. It provides an opportunity to study up to twelve patients simultaneously at distances up to 30 m from the instrument, can operate for prolonged periods without intervention, and includes a routine for regular calibration checks. There is an automatic sensitivity control which compensates for minor variations in probe patency or in water… 

Respiratory mass spectrometry during general anaesthesia.

The performance of a respiratory mass spectrometer, modified commercially for use during general anaesthesia, has been evaluated. Stability and linearity proved satisfactory for monitoring

Mass Spectrometry in the Intensive Care Unit

This report evaluates a system, based on the Centronic MGA 200 respiratory mass spectrometer, which has been installed in the intensive care unit of a specialised cardiothoracic hospital.

Remote monitoring by mass spectrometry during anaesthesia. Evaluation of a suitable inlet system.

Results compared with those of other workers support the chosen compromise between practical flexibility and convenience versus maximum speed of response that was adopted in this system design.

Mass spectrometer for respiratory research

  • R. Arieli
  • Medicine
    Respiratory Physiology & Neurobiology
  • 2010

An automated mechanism for protection of mass spectrometry sampling tubing

An automated system consisting of an infrared light sensor and a three-way valve that has decreased the cost of operating mass spectrometers while also reducing periods of unavailability due to equipment failure is developed.

A multipatient mass spectrometer based system for the measurement of metabolic gas exchange in artificially ventilated intensive care patients

The MPMS measurements of metabolic gas exchange were found to have insignificant systematic errors with precisions of ±12 ml/min VO2, ±7 ml/Min VCO2,±0.03 RQ and ±0.1 l/min Ve; (2SD).

Evaluation of long sampling tubes for remote monitoring by mass spectrometry

The long sampling tubes required for remote mass spectrometry alter the sampling system’s performance characterized by sample flow, residence time, and 10 to 90% response time, so an easy-to-handle tube is searched for that allows the accurate monitoring of breathing frequencies up to 25 and 50 breaths/min for volatile agents and gases.

Monitoring respiratory function in the critically ill

Equipment has been developed which allows breath by breath recording of carbon dioxide concentration using stable, simple apparatus which does not require frequent recalibration with known gas mixtures and is suitable for use in both spontaneously breathing, conscious subjects and for those requiring mechanical ventilation.

A gas mixer for computer calibration of an anesthetic mass spectrometer

To calibrate an anesthetic mass spectrometer without the use of premixed gases and vapors in cylinders, we devised a gas mixer using fixed resistances of capillary needle tubings and adjustable

End-tidal carbon dioxide as a measure of arterial carbon dioxide during intermittent mandatory ventilation

Monitoring the maximalPetCO2, independent of breathing pattern, provides a clinically useful indicator of PaCO2 in postcardiotomy patients receiving intermittent mandatory ventilation.



A pressure-operated collect valve for respiratory studies during intermittent positive pressure ventilation.

During the inflation phase of intermittent positive pressure ventilation gas is compressed in the tubes and connections between the valves of the ventilator and the patient. In machines where the

A system for monitoring arterial oxygen tension in sick newborn babies.

The results obtained with these transducers in the first eighteen babies are reported in detail and demonstrate the possibility of continuous, reliable measurement of PaO2 under routine clinical conditions.

Lung tissue volume and blood flow by rebreathing theory.

Estimates of Vt and Qc have acceptable accuracy in normal man and subjects with moderate degree of uneven distribution, but large errors develop with more severe forms of lung disease.

pressure-operated collected valve for respiratory studies during intermittent positive pressure ventilation

  • British Journal of Anaesthesia
  • 1969

The use of long sampling probes in respiratory mass spectrometry. Respiration

  • Physiology
  • 1979