Applications of quantitative measurements for assessing glutamate neurotoxicity.

  title={Applications of quantitative measurements for assessing glutamate neurotoxicity.},
  author={S Finkbeiner and Charles F. Stevens},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={85 11},
The role of the N-methyl-D-aspartate receptor channel in glutamate neurotoxicity was investigated in cultured hippocampal neurons of the CA1 region. An equation, the survival function, was developed to quantify the effects of putative modulators of neurotoxicity. 2-Amino-5-phosphonovaleric acid (30 microM) reduced the neuronal sensitivity to glutamate by a factor greater than 20, whereas glycine (1 microM) enhanced it by a factor of 7.5 +/- 2.5. Neurons were protected by increasing Mg2… CONTINUE READING
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