Applications of multicomponent reactions to the synthesis of diverse heterocyclic scaffolds.

@article{Sunderhaus2009ApplicationsOM,
  title={Applications of multicomponent reactions to the synthesis of diverse heterocyclic scaffolds.},
  author={James D. Sunderhaus and Stephen F Martin},
  journal={Chemistry},
  year={2009},
  volume={15 6},
  pages={
          1300-8
        }
}
The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions is a powerful stratagem for the rapid synthesis of diverse heterocyclic scaffolds. The optimal MCR is sufficiently flexible that it can be employed to generate adducts bearing a variety of functional groups that may then be selectively paired to enable different cyclization manifolds, thereby leading to a diverse collection of products. The growing interest in diversity-oriented synthesis has led to increased… Expand
Multicomponent reactions for the synthesis of heterocycles.
A multicomponent reaction towards N-(cyanomethyl)amides.
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