Applications of multicomponent reactions for the synthesis of diverse heterocyclic scaffolds.

@article{Sunderhaus2007ApplicationsOM,
  title={Applications of multicomponent reactions for the synthesis of diverse heterocyclic scaffolds.},
  author={James D Sunderhaus and Chris Dockendorff and Stephen F Martin},
  journal={Organic letters},
  year={2007},
  volume={9 21},
  pages={4223-6}
}
A four-component coupling process involving sequential reactions of aldehydes, primary amines, acid chlorides, and nucleophiles has been developed to prepare multifunctional substrates that may be employed in subsequent ring-forming reactions to generate a diverse array of functionalized heterocyclic scaffolds. This new approach to diversity-oriented synthesis was then applied to the first total synthesis of the isopavine alkaloid (+/-)-roelactamine.