Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

@article{Lundberg2008ApplicationsOL,
  title={Applications of lentiviral vectors for biology and gene therapy of neurological disorders.},
  author={Cecilia Lundberg and Tomas Bj{\"o}rklund and Thomas Carlsson and Johan Jakobsson and Philippe Hantraye and Nicole D{\'e}glon and Deniz Kirik},
  journal={Current gene therapy},
  year={2008},
  volume={8 6},
  pages={
          461-73
        }
}
Recombinant lentiviral vectors (rLV) are powerful tools for gene transfer to the central nervous system (CNS) and hold great potential as a therapeutic gene therapy strategy for neurological disorders. Recent data indicate that rLVs are suitable for functional studies in the CNS by over expression or knock down of specific proteins. Based on a variety of lentiviruses species, different vector systems have been developed. However, the most commonly used rLV vector is based on the human… CONTINUE READING