Applications of immunohistochemistry in the evaluation of immunosuppressive agents

  title={Applications of immunohistochemistry in the evaluation of immunosuppressive agents},
  author={Nancy A. Gillett and C. Chan},
  journal={Human and Experimental Toxicology},
  pages={251 - 254}
  • N. Gillett, C. Chan
  • Published 1 April 2000
  • Biology, Medicine
  • Human and Experimental Toxicology
Immunohistochemistry (IHC) can be a valuable endpoint to evaluate lymphocyte subpopulations in tissues following exposure to presumptive immunosuppressive agents. IHC is more sensitive than conventional histology in detecting subtle differences in lymphocyte numbers and distribution in tissue. In combination with flow cytometric analysis of peripheral lymphocyte subpopulations, IHC can determine if alterations detected in the peripheral blood are a result of trafficking or reflective of changes… 

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