Applications of high-throughput ADME in drug discovery.

  title={Applications of high-throughput ADME in drug discovery.},
  author={Daniel B Kassel},
  journal={Current opinion in chemical biology},
  volume={8 3},
Assessment of physicochemical and pharmacological properties is now conducted at very early stages of drug discovery for the purpose of accelerating the conversion of hits and leads into qualified development candidates. In particular, in vitro absorption, distribution, metabolism and elimination (ADME) assays and in vivo drug metabolism pharmacokinetic (DMPK) studies are being conducted throughout the discovery process, from hit generation through to lead optimization, with the goal of… CONTINUE READING