Gene Therapy for the Treatment of Cancer
- Biology, Medicine
The purpose of this chapter is to provide a general background on how genes are transferred as well as a specific example focusing on the translation of a gene therapy study from inception through a completed Phase III clinical trial.
Analysis of the Impact of Genetic Engineering on China's Economy
At the genetic level, a method similar to engineering design is adopted, designed according to human needs, and then a new biological strain with a certain new trait is created according to the…
Lipídios catiônicos anfifílicos, como neutralizadores da carga elétrica do DNA para transfecção in vitro de células eucarióticas.
- Biology, Chemistry
The viability of a new theory which proposes the use of amphiphilic molecules to neutralize the DNA charge in order to transfect DNA in vitro is studied and the DDAB system has proven simple, economic, and relatively efficient for the transfection of cell lines using either linear or circular plasmids.
Development of a Western Blot Assay for Detection of Bovine Immunodeficiency-Like Virus Using Capsid and Transmembrane Envelope Proteins Expressed from Recombinant Baculovirus
- BiologyClinical Diagnostic Laboratory Immunology
The results of this study showed that the recombinant p26 and tTM proteins can be used as test antigens for the serodetection of BIV-infection in animals.
White Shaker Disease Syndrome
The cause of the disease is not known and there is little research being done on this condition in any breed, so the terms “shaker dog syndrome”, “white shaker disease” and “little white shaker dog” have been used as synonyms.
Synthesis and cellular uptake of cell delivering PNA-peptide conjugates.
- Biology, ChemistryChemical communications
Dde/Mmt protected PNA monomers were used to develop a flexible strategy to give Peptide Nucleic Acids conjugated to tri- and hepta-arginine and the short basic Tat(48-57) peptide as examples of cellular penetrating peptides, thereby allowing efficient cellular delivery of PNA into cells.
Enabling broad use of genome modification technologies to solve real world problems: A specific application in peanut
The functionality of various CRISPR design tools is reviewed to help researchers choose a tool that best suits their specific research needs including their own, theCRISPR Genome Analysis Tool (CGAT).
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Cancer gene therapy--fantasy or foresight?
- BiologyAnnals of the Academy of Medicine, Singapore
It is reassuring that recent advances in gene therapy provide abundant evidence that the premature infant, born of unrealistic pressure, is indeed healthy and thriving, and the folly of underestimating the technical complexity of gene manipulation in human diseases is exposed.
Use of biotechnical methods in veterinary medicine.
- BiologyRevue scientifique et technique
Production of monoclonal antibodies directed against viral and bacteria-specific antigens such as bovine virus diarrhoea virus, classical swine fever virus, feline leukaemia virus, animal parvoviruses, Alphavirus, Brucella and Francisella is used.
Gene therapy: lessons learnt from the past decade
- Biology, MedicineBMJ
Gene therapy is now a robust scientific discipline with an array of new reagents which will soon be ready for specific clinical applications, and initial speculation that gene therapy would quickly revolutionise medicine has clearly been wrong.
[DNA diagnosis in veterinary medicine: II. Polymerase chain reaction (PCR)].
- Biology, MedicineSchweizer Archiv fur Tierheilkunde
The purpose of this minireview is to give an introduction into the basic technique of polymerase chain reaction and to mention possible and already existing applications in veterinary medicine.
The molecular basis of canine melanoma: pathogenesis and trends in diagnosis and therapy.
- Medicine, BiologyJournal of veterinary internal medicine
The advantages of an improved understanding of the molecular basis of canine cancer are underscored by recent promising advances in diagnosis and in immunologic and genetic therapies that may help reduce the mortality of dogs affected with malignant melanoma.
Development of human granulocyte-macrophage colony-stimulating factor-transfected tumor cell vaccines for the treatment of spontaneous canine cancer.
- Biology, MedicineHuman gene therapy
In vivo biological activity of hGM-CSF-transfected autologous tumor cell vaccines are demonstrated, in a large animal translational model of spontaneous tumors, to demonstrate a systemic antitumor response.
Canine hemophilia B resulting from a point mutation with unusual consequences.
- BiologyProceedings of the National Academy of Sciences of the United States of America
The polymerase chain reaction is used to amplify the entire coding region of canine factor IX from a hemophilia B animal and a single missense mutation is identified that results in a complete lack of circulating factor IX in the affected animals.
Biological response modifiers: interferons, interleukins, recombinant products, liposomal products.
- BiologyThe Veterinary clinics of North America. Small animal practice
Advances toward gene therapy for hemophilia at the millennium.
- Biology, MedicineHuman gene therapy
Although progress with gene transfer of factor IX has proceeded at a greater rate than factor VIII, success with both molecules has demonstrated partial persistent correction in mouse and canine models of hemophilia A and B.