Applications of fluorescence and bioluminescence resonance energy transfer to drug discovery at G protein coupled receptors.

@article{AlvarezCurto2004ApplicationsOF,
  title={Applications of fluorescence and bioluminescence resonance energy transfer to drug discovery at G protein coupled receptors.},
  author={Elisa Alvarez-Curto and John D. Pediani and Graeme Milligan},
  journal={Analytical and bioanalytical chemistry},
  year={2004},
  volume={398 1},
  pages={
          167-80
        }
}
The role of G protein coupled receptors (GPCRs) in numerous physiological processes that may be disrupted or modified in disease makes them key targets for the development of new therapeutic medicines. A wide variety of resonance energy transfer (RET) techniques such as fluorescence RET and bioluminescence RET have been developed in recent years to detect protein-protein interactions in living cells. Furthermore, these techniques are now being exploited to screen for novel compounds that… CONTINUE READING
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