Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential.

@article{Xu2004ApplicationsOC,
  title={Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential.},
  author={Jinghai James Xu and Dolores D{\'i}az and Peter James O'Brien},
  journal={Chemico-biological interactions},
  year={2004},
  volume={150 1},
  pages={115-28}
}
While drug toxicity (especially hepatotoxicity) is the most frequent reason cited for withdrawal of an approved drug, no simple solution exists to adequately predict such adverse events. Simple cytotoxicity assays in HepG2 cells are relatively insensitive to human hepatotoxic drugs in a retrospective analysis of marketed pharmaceuticals. In comparison, a panel of pre-lethal mechanistic cellular assays hold the promise to deliver a more sensitive approach to detect endpoint-specific drug… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

The use of hepatocytes to investigate drug toxicity.

Methods in molecular biology • 2010
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…