Applications of computational modeling in metabolic engineering of yeast.

@article{Kerkhoven2015ApplicationsOC,
  title={Applications of computational modeling in metabolic engineering of yeast.},
  author={Eduard J. Kerkhoven and Petri-Jaan Lahtvee and Jens B Nielsen},
  journal={FEMS yeast research},
  year={2015},
  volume={15 1},
  pages={1-13}
}
Generally, a microorganism's phenotype can be described by its pattern of metabolic fluxes. Although fluxes cannot be measured directly, inference of fluxes is well established. In biotechnology the aim is often to increase the capacity of specific fluxes. For this, metabolic engineering methods have been developed and applied extensively. Many of these rely on balancing of intracellular metabolites, redox, and energy fluxes, using genome-scale models (GEMs) that in combination with appropriate… CONTINUE READING
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