Applications of antigen receptor gene rearrangements to the diagnosis and characterization of lymphoid neoplasms.

@article{Sklar1988ApplicationsOA,
  title={Applications of antigen receptor gene rearrangements to the diagnosis and characterization of lymphoid neoplasms.},
  author={Jessica Sklar and Lawrence M. Weiss},
  journal={Annual review of medicine},
  year={1988},
  volume={39},
  pages={315-34}
}
During early stages of lymphocyte development, genes for antigen receptors (immunoglobulin and T-cell receptor proteins) undergo rearrangements of their DNA sequences. The resulting configurations of rearranged DNA are highly variable from cell to cell and serve as genetic markers for individual lymphocytes. These markers can be utilized to detect clonal… CONTINUE READING