Corpus ID: 55400506

Applications of In Silico Methodologies in Exploring the InhibitoryPotentials of Fisetin on MMP-8 and MMP-13 in Colorectal CancerProgression

  title={Applications of In Silico Methodologies in Exploring the InhibitoryPotentials of Fisetin on MMP-8 and MMP-13 in Colorectal CancerProgression},
  author={Arowosegbe Michael Aderibigbe and Ogunleye Adewale Joseph and O. EniafeGabriel and O. Idowu and Ehima Victoria Obiajuru and M. D. Samuel and Ogungbe Bimpe and Kanmodi Rahmon Ilesanmi and Ogunmola Oluwafemi Jude},
  journal={International Journal of Drug Development and Research},
Matrix metalloproteinases, MMP-8 and MMP-13, play crucial roles in the prognosis of colorectal cancer (CRC). Although some literatures consider MMP-8 as a double-edged sword, based on its ambiguous effects in tumouriogenesis. A conglomeration of evidence has revealed that MMP-8 and MMP-13 are requisite in the degradation and remodelling of components of the extracellular matrix in colorectal cancer progression. Therefore, it is apposite to timely inhibit these Zn-dependent endopeptidases… Expand
Applications of In Silico Methodologies in Exploring the InhibitoryPotentials of Fisetin on MMP-8 and MMP-13 in Colorectal CancerProgression
Findings from this study corroborate other findings, indicating that fisetin is probable potent anticancer drug and it can significantly palliate CRC invasion and metastasis. Expand


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