Applications of Genetic Algorithms on the Structure-Activity Relationship Analysis of Some Cinnamamides


Quantitative structure-activity relationships (QSARs) for 35 cinnamamides were studied. By using a genetic algorithm (GA), a group of multiple regression models with high fitness scores was generated. From the statistical analyses of the descriptors used in the evolution procedure, the principal features affecting the anticonvulsant activity were found. The… (More)
DOI: 10.1021/ci990010n


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