Applications of CRISPR technologies in research and beyond

@article{Barrangou2016ApplicationsOC,
  title={Applications of CRISPR technologies in research and beyond},
  author={R. Barrangou and J. Doudna},
  journal={Nature Biotechnology},
  year={2016},
  volume={34},
  pages={933-941}
}
Programmable DNA cleavage using CRISPR–Cas9 enables efficient, site-specific genome engineering in single cells and whole organisms. In the research arena, versatile CRISPR-enabled genome editing has been used in various ways, such as controlling transcription, modifying epigenomes, conducting genome-wide screens and imaging chromosomes. CRISPR systems are already being used to alleviate genetic disorders in animals and are likely to be employed soon in the clinic to treat human diseases of the… Expand
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