Applications of 3D-QSAR and structure-based pharmacophore modeling, virtual screening, ADMET, and molecular docking of putative MAPKAP-K2 (MK2) inhibitors

Abstract

MAPKAP-K2 (MK2) belongs to the Ser/Thr kinase family, and has emerged as a highly favored target in the search for efficacious and safe anti-inflammatory drug. Thus, 3D-QSAR and structure-based pharmacophore models were developed in this study to identify new potential leads inhibiting MK2 as an efficient way to treat rheumatoid arthritis. Furthermore… (More)
DOI: 10.1007/s00044-013-0492-9

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@article{Wang2013ApplicationsO3, title={Applications of 3D-QSAR and structure-based pharmacophore modeling, virtual screening, ADMET, and molecular docking of putative MAPKAP-K2 (MK2) inhibitors}, author={Tai-Jin Wang and Lu Zhou and Jia Fei and Zi-cheng Li and Lu-fen He}, journal={Medicinal Chemistry Research}, year={2013}, volume={22}, pages={4818-4829} }