Applications for ROCK kinase inhibition.

Abstract

ROCK kinases, which play central roles in the organization of the actin cytoskeleton, are tantalizing targets for the treatment of human diseases. Deletion of ROCK I in mice revealed a role in the pathophysiological responses to high blood pressure, and validated ROCK inhibition for the treatment of specific types of cardiovascular disease. To date, the… (More)
DOI: 10.1016/j.ceb.2008.01.002

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