Application of the yeast-surface-display system for orally administered salmon calcitonin and safety assessment.

Abstract

High manufacturing costs and oral delivery are the constraints in clinical application of calcitonin. We selected surface-displayed Saccharomyces cerevisiae as a low-cost and safe carrier for oral delivery of salmon calcitonin (sCT). The sCT DNA fragment, optimized according to the codon preference of S. cerevisiae, was synthesized and cloned into the… (More)
DOI: 10.1002/btpr.413

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