Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis

@article{Dalton2002ApplicationOT,
  title={Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis},
  author={Catherine M. Dalton and Peter A. Brex and Katherine A. Miszkiel and Simon J. Hickman and David G. MacManus and Gordon T. Plant and Alan J. Thompson and David H. Miller},
  journal={Annals of Neurology},
  year={2002},
  volume={52}
}
Traditionally, multiple sclerosis (MS) has been diagnosed on the basis of clinical evidence of dissemination in time and space. Previously, it could not be diagnosed in patients with single clinical episodes of demyelination known as clinically isolated syndromes. New diagnostic criteria from the International Panel of McDonald and colleagues incorporate MRI evidence of dissemination in time and space to allow a diagnosis of MS in patients with clinically isolated syndromes. From clinical and… 
New diagnostic criteria for multiple sclerosis
TLDR
One year after symptom onset, more than three times as many patients with CIS were diagnosed with MS using new diagnostic criteria incorporating MRI results compared to older criteria, however, the proposed MRI criteria require further prospective studies to optimize sensitivity and specificity.
New diagnostic criteria for multiple sclerosis
TLDR
One year after symptom onset, more than three times as many patients with CIS were diagnosed with MS using new diagnostic criteria incorporating MRI results compared to older criteria, however, the proposed MRI criteria require further prospective studies to optimize sensitivity and specificity.
Application of the 2010 McDonald criteria for the diagnosis of multiple sclerosis in a Spanish cohort of patients with clinically isolated syndromes
TLDR
The sensitivity of DIT criterion using a single MRI scan was rather low, as other previous studies showed, but it could improve the accuracy of early MS diagnosis in that group of patients with typical CIS and gadolinium-enhancing and non-enhanced lesions on their baseline scans.
Modification of MRI criteria for multiple sclerosis in patients with clinically isolated syndromes
TLDR
The modified McDonald criteria for dissemination in space and time for assessing the development of clinically definite multiple sclerosis were more sensitive and more accurate than the original criteria.
Application of the McDonald 2010 criteria for the diagnosis of multiple sclerosis in an Argentinean cohort of patients with clinically isolated syndromes
TLDR
A study assessing McDonald 2010 criteria in a Latin-American population may contribute to its international validation by showing a high level of accuracy for these new diagnostic criteria in this local ethnic/genetic population.
Accuracy of MRI criteria for dissemination in space for the diagnosis of multiple sclerosis in patients with clinically isolated syndromes
TLDR
Swanton’s criteria are simpler and more sensitive than Barkhof—Tintoré‘s criteria, with a slight decrease in specificity, which reinforce their use in multiple sclerosis diagnosis.
Application of the 2017 Revised McDonald Criteria for Multiple Sclerosis to Patients With a Typical Clinically Isolated Syndrome
TLDR
The 2017 revised McDonald criteria is associated with greater sensitivity but less specificity for a second attack than the previous 2010 criteria, which leads to a higher number of MS diagnoses in patients with a less active disease course.
Updates on Clinically Isolated Syndrome and Diagnostic Criteria for Multiple Sclerosis
TLDR
Clinically isolated syndrome (CIS) is a central nervous system demyelinating event isolated in time that is compatible with the possible future development of multiple sclerosis (MS) and magnetic resonance imaging (MRI) is currently the most useful tool to evaluate risk.
MRI criteria for MS in patients with clinically isolated syndromes
TLDR
Information that may simplify the existing MS diagnostic criteria, while maintaining a high specificity that is essential to minimize false positive diagnoses is reviewed and discussed and integrated in this position paper.
Clinically Isolated Syndromes : Clinical Characteristics , Differential Diagnosis , and Management Klinik
TLDR
As CIS is typically the earliest clinical expression of MS, research on patients with CIS may provide new insights into early pathological changes and pathogenetic mechanisms that might affect the course of the disorder.
...
...

References

SHOWING 1-10 OF 39 REFERENCES
Isolated demyelinating syndromes: comparison of different MR imaging criteria to predict conversion to clinically definite multiple sclerosis.
TLDR
The four dichotomized MR imaging parameters proposed by Barkhof et al are more specific and accurate than the criteria proposed by Paty et al or Fazekas et al for predicting conversion to clinically definite multiple sclerosis.
Assessing the risk of early multiple sclerosis in patients with clinically isolated syndromes: the role of a follow up MRI
TLDR
Serial imaging in patients with clinically isolated syndromes improved the positive predictive value, sensitivity, and specificity of MRI for the development of early multiple sclerosis and also identified patients at a lower risk of earlymultiple sclerosis than would have been expected from their abnormal baseline MRI.
The prognostic value of brain MRI in clinically isolated syndromes of the CNS. A 10-year follow-up.
TLDR
Brain MRI at presentation with a clinically isolated syndrome is predictive of the long-term risk of subsequent development of multiple sclerosis, the type of disease and extent of disability.
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
TLDR
It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
MRI in the diagnosis of MS
TLDR
MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
TLDR
Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Isolated demyelinating syndromes: comparison of CSF oligoclonal bands and different MR imaging criteria to predict conversion to CDMS
TLDR
A high prevalence of OB in CIS is observed and OB and MR imaging (Paty's and Fazekas' criteria) have high sensitivity and Barkhof's criteria have a higher specificity.
Multisequence MRI in clinically isolated syndromes and the early development of MS
TLDR
The combination of baseline MRI abnormalities and new lesions at follow-up, indicating dissemination in space and time, was associated with a high sensitivity and specificity for the early development of clinical MS.
Magnetization transfer imaging in patients with clinically isolated syndromes suggestive of multiple sclerosis.
TLDR
The reduced MTR in NAWM, described in established MS, was not detectable in patients with CIS, and MTR did not provide prognostic information for this short period of follow-up.
The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability.
TLDR
The outcome of multiple sclerosis, assessed according to the Kurtzke Disability Status Scale, was reviewed in 1,099 consecutive patients followed in London, Canada, between 1972 and 1984 and the rate at which disability develops after the onset of a progressive phase of MS is presented.
...
...