Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis

@article{Dalton2002ApplicationOT,
  title={Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis},
  author={Catherine M. Dalton and Peter A. Brex and Katherine A. Miszkiel and Simon J. Hickman and David G. MacManus and Gordon T. Plant and Alan J. Thompson and David H. Miller},
  journal={Annals of Neurology},
  year={2002},
  volume={52}
}
Traditionally, multiple sclerosis (MS) has been diagnosed on the basis of clinical evidence of dissemination in time and space. Previously, it could not be diagnosed in patients with single clinical episodes of demyelination known as clinically isolated syndromes. New diagnostic criteria from the International Panel of McDonald and colleagues incorporate MRI evidence of dissemination in time and space to allow a diagnosis of MS in patients with clinically isolated syndromes. From clinical and… 

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Clinically Isolated Syndromes: Clinical Characteristics, Differential Diagnosis, and Management.

  • H. Efendi
  • Medicine, Psychology
    Noro psikiyatri arsivi
  • 2015
TLDR
As CIS is typically the earliest clinical expression of MS, research on patients with CIS may provide new insights into early pathological changes and pathogenetic mechanisms that might affect the course of the disorder.
...

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