Application of the neuroblastoma assay for paralytic shellfish poisons to neurotoxic freshwater cyanobacteria: interlaboratory calibration and comparison with other methods of analysis.

@article{Humpage2007ApplicationOT,
  title={Application of the neuroblastoma assay for paralytic shellfish poisons to neurotoxic freshwater cyanobacteria: interlaboratory calibration and comparison with other methods of analysis.},
  author={Andrew R. Humpage and Aur{\'e}lie Ledreux and Stella Fanok and C{\'e}cile Bernard and Jean-François Briand and Geoff Eaglesham and John Papageorgiou and Brenton C. Nicholson and Dennis A Steffensen},
  journal={Environmental toxicology and chemistry},
  year={2007},
  volume={26 7},
  pages={1512-9}
}
Paralytic shellfish poisons (PSPs) are produced by freshwater cyanobacteria and pose a threat to human and animal drinking-water supplies. The wide range of toxin analogues (and the likelihood that further analogues remain to be discovered) means that chromatographic methods are not always reliable indicators of toxicity. Although the mouse bioassay remains the method of choice in the seafood industry, its use is increasingly being questioned on ethical grounds. The cell-based Neuro-2A… CONTINUE READING

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