Application of the Photoredox Coupling of Trifluoroborates and Aryl Bromides to Analog Generation Using Continuous Flow.

Abstract

A method for the coupling of aryl bromides with potassium alkyl trifluoroborates, via nickel/photoredox dual catalysis, has been developed for use in continuous flow. This operationally simple protocol is able to form Csp3-Csp2 bonds with significantly reduced reaction times and a broader substrate scope than when conducted in batch. The utility of this method for rapid analog synthesis has been demonstrated by the synthesis of a small library of alkyl-substituted quinazolines.

Cite this paper

@article{DeLano2016ApplicationOT, title={Application of the Photoredox Coupling of Trifluoroborates and Aryl Bromides to Analog Generation Using Continuous Flow.}, author={Travis J DeLano and Upul K Bandarage and Natalie Palaychuk and Jeremy Green and Michael J Boyd}, journal={The Journal of organic chemistry}, year={2016}, volume={81 24}, pages={12525-12531} }