Application of the FICTION technique for the simultaneous detection of immunophenotype and chromosomal abnormalities in routinely fixed, paraffin wax embedded bone marrow trephines.

@article{Korac2005ApplicationOT,
  title={Application of the FICTION technique for the simultaneous detection of immunophenotype and chromosomal abnormalities in routinely fixed, paraffin wax embedded bone marrow trephines.},
  author={P Korac and Margaret D. Jones and Marija Dominis and Rajko Ku{\vs}ec and David Mason and Alison H Banham and Roland A Ventura},
  journal={Journal of clinical pathology},
  year={2005},
  volume={58 12},
  pages={1336-8}
}
The use of interphase fluorescence in situ hybridisation (FISH) to study cytogenetic abnormalities in routinely fixed paraffin wax embedded tissue has become commonplace over the past decade. However, very few studies have applied FISH to routinely fixed bone marrow trephines (BMTs). This may be because of the acid based decalcification methods that are commonly used during the processing of BMTs, which may adversely affect the suitability of the sample for FISH analysis. For the first time… CONTINUE READING

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