Application of surface plasmon resonance imaging technique for the detection of single spherical biological submicrometer particles.

@article{Shpacovitch2015ApplicationOS,
  title={Application of surface plasmon resonance imaging technique for the detection of single spherical biological submicrometer particles.},
  author={Victoria Shpacovitch and Vladimir Temchura and Mikhail Matrosovich and Joachim Hamacher and Julia Skolnik and Pascal Libuschewski and Dominic Siedhoff and Frank Weichert and Peter Marwedel and Heinrich M{\"u}ller and Klaus {\"U}berla and Roland Hergenr{\"o}der and Alexander Zybin},
  journal={Analytical biochemistry},
  year={2015},
  volume={486},
  pages={62-9}
}
Recent proof-of-principle studies demonstrated the suitability of the surface plasmon resonance imaging (SPRi) technique for the detection of individual submicrometer and nanoparticles in solutions. In the current study, we used the SPRi technique for visualization of the binding of round-shaped viruses (inactivated influenza A virus) and virus-like particles (human immunodeficiency virus (HIV)-based virus-like particles) to the functionalized sensor surface. We show the applicability of the… CONTINUE READING