Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin.

@article{Iwanaga1999ApplicationOS,
  title={Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin.},
  author={Kazunori Iwanaga and Satoko Ono and Kenichi Narioka and Masawo Kakemi and Kazuhiro Morimoto and Shinji Yamashita and Yukihiro Namba and Naoto Oku},
  journal={Journal of pharmaceutical sciences},
  year={1999},
  volume={88 2},
  pages={248-52}
}
We prepared two kinds of surface-coated liposomes and investigated their potencies as oral dosage forms for peptide drugs by focusing on their effects on the gastrointestinal (GI) transit of drugs. The surface of the liposomes was coated with poly(ethylene glycol) 2000 (PEG-Lip) or the sugar chain of mucin (Mucin-Lip). As a model peptide drug, insulin was encapsulated in these liposomes. Coating the surface with poly(ethylene glycol) was found to reduce the transit rate of liposomes in the… CONTINUE READING
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