Application of solution calorimetry in pharmaceutical and biopharmaceutical research.

@article{Royall2005ApplicationOS,
  title={Application of solution calorimetry in pharmaceutical and biopharmaceutical research.},
  author={Paul G. Royall and Simon Gaisford},
  journal={Current pharmaceutical biotechnology},
  year={2005},
  volume={6 3},
  pages={
          215-22
        }
}
In solution calorimetry the heat of solution (Delta(sol)H) is recorded as a solute (usually a solid) dissolves in an excess of solvent. Such measurements are valuable during all the phases of pharmaceutical formulation and the number of applications of the technique is growing. For instance, solution calorimetry is extremely useful during preformulation for the detection and quantification of polymorphs, degrees of crystallinity and percent amorphous content; knowledge of all of these… CONTINUE READING

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