Application of response surface methods for evaluating the interactions of soman, atropine, and pralidioxime chloride.

@article{Carter1985ApplicationOR,
  title={Application of response surface methods for evaluating the interactions of soman, atropine, and pralidioxime chloride.},
  author={Walter H. Carter and David E. J. Jones and Richard A. Carchman},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1985},
  volume={5 6 Pt 2},
  pages={S232-41}
}
Response surface methods were employed to model survival data obtained in guinea pigs following subcutaneous exposure to soman (GD; 30-84.6 micrograms/kg) with various treatment regimens (i.e., atropine/pralidioxime chloride [ATR/2-PAM] combinations, given im, 1 min post-GD). The analysis of the proportions of surviving animals in the various groups revealed that the use of individual treatment agents (i.e., ATR or 2-PAM) was effective in increasing survival. The level of GD exposure altered… CONTINUE READING

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