Application of quantum dots to multicolor microarray experiments: four-color genotyping.

@article{KarlinNeumann2007ApplicationOQ,
  title={Application of quantum dots to multicolor microarray experiments: four-color genotyping.},
  author={George Karlin-Neumann and Marina Sedova and Mat Falkowski and Zhiyong Wang and Steven H Lin and Maneesh Jain},
  journal={Methods in molecular biology},
  year={2007},
  volume={374},
  pages={239-51}
}
Highly multiplexed genomics assays are challenged by the need for a sufficient signal-to-noise ratio for each marker scored on a microarray-detection platform. Typically, as the number of markers scored (or target complexity) increases, either more assay-target material must be applied to the array or the specific activity of each marker must be proportionately increased. However, hybridization of excessive amounts of target to the microarray can result in elevated nonspecific binding and… CONTINUE READING