Application of protein microarrays for multiplexed detection of antibodies to tumor antigens in breast cancer.

@article{Anderson2008ApplicationOP,
  title={Application of protein microarrays for multiplexed detection of antibodies to tumor antigens in breast cancer.},
  author={Karen S. Anderson and Niroshan Ramachandran and Jessica J Wong and Jacob V. Raphael and Eugenie Hainsworth and Gokhan Demirkan and Daniel C Cramer and Dina Aronzon and Frank Stephen Hodi and Lyndsay Harris and Tanya Logvinenko and Joshua LaBaer},
  journal={Journal of proteome research},
  year={2008},
  volume={7 4},
  pages={
          1490-9
        }
}
There is strong preclinical evidence that cancer, including breast cancer, undergoes immune surveillance. This continual monitoring, by both the innate and the adaptive immune systems, recognizes changes in protein expression, mutation, folding, glycosylation, and degradation. Local immune responses to tumor antigens are amplified in draining lymph nodes, and then enter the systemic circulation. The antibody response to tumor antigens, such as p53 protein, are robust, stable, and easily… CONTINUE READING

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