Application of proteases to the identification of chiral modifications in synthetic peptides.

  • Kevin Keating
  • Published 1999 in Journal of biomolecular techniques : JBT

Abstract

Racemization of amino acids during solid-phase synthesis of peptides leads to the formation of side products that are chirally modified peptides. The chiral specificity of enzymes can be exploited to identify the sites of the modifications in these impurities. One such impurity, designated X5, was isolated from the target peptide, Fel-1, and demonstrated to… (More)

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