Application of process analytical technology in tablet process development using NIR spectroscopy: blend uniformity, content uniformity and coating thickness measurements.

@article{Moes2008ApplicationOP,
  title={Application of process analytical technology in tablet process development using NIR spectroscopy: blend uniformity, content uniformity and coating thickness measurements.},
  author={Johannes J Moes and Marco Ruijken and Erik Gout and Henderik W Frijlink and Michael Ikechukwu Ugwoke},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={357 1-2},
  pages={
          108-18
        }
}
Near-infrared (NIR) spectroscopy was employed as a process analytical technique in three steps of tabletting process: to monitor the blend homogeneity, evaluate the content uniformity of tablets and determine the tablets coating thickness. A diode-array spectrometer mounted on a lab blender (SP15 NIR lab blender) was used to monitor blend uniformity using a calibration-free model with drug concentration ranging from 2.98 to 9.25% (w/w). The method developed accurately depicted the changes in… CONTINUE READING

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