Application of principal component analysis to pharmacogenomic studies in Canada

@article{Visscher2009ApplicationOP,
  title={Application of principal component analysis to pharmacogenomic studies in Canada},
  author={H. W. Visscher and C J D Ross and M-P Dub{\'e} and Andrew M. K. Brown and Michael S. Phillips and Bruce Carleton and Michael R. Hayden},
  journal={The Pharmacogenomics Journal},
  year={2009},
  volume={9},
  pages={362-372}
}
Ethnicity can confound results in pharmacogenomic studies. Allele frequencies of loci that influence drug metabolism can vary substantially between different ethnicities and underlying ancestral genetic differences can lead to spurious findings in pharmacogenomic association studies. We evaluated the application of principal component analysis (PCA) in a pharmacogenomic study in Canada to detect and correct for genetic ancestry differences using genotype data from 2094 loci in 220 key drug… CONTINUE READING

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