Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients.

@article{Gajewska2014ApplicationOP,
  title={Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients.},
  author={Monika Anna Gajewska and Andrew P. Worth and Chiara Urani and Heiko Briesen and Karl-Werner Schramm},
  journal={Toxicology letters},
  year={2014},
  volume={227 3},
  pages={
          189-202
        }
}
The application of physiologically based toxicokinetic (PBTK) modelling in route-to-route (RtR) extrapolation of three cosmetic ingredients: coumarin, hydroquinone and caffeine is shown in this study. In particular, the oral no-observed-adverse-effect-level (NOAEL) doses of these chemicals are extrapolated to their corresponding dermal values by comparing the internal concentrations resulting from oral and dermal exposure scenarios. The PBTK model structure has been constructed to give a good… CONTINUE READING
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