Application of physiologically based pharmacokinetic modeling in setting acute exposure guideline levels for methylene chloride.

@article{Bos2006ApplicationOP,
  title={Application of physiologically based pharmacokinetic modeling in setting acute exposure guideline levels for methylene chloride.},
  author={Peter Martinus Jozef Bos and Marco Jacob Zeilmaker and Jan Cornelis Henri van Eijkeren},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2006},
  volume={91 2},
  pages={576-85}
}
Acute exposure guideline levels (AEGLs) are derived to protect the human population from adverse health effects in case of single exposure due to an accidental release of chemicals into the atmosphere. AEGLs are set at three different levels of increasing toxicity for exposure durations ranging from 10 min to 8 h. In the AEGL setting for methylene chloride, specific additional topics had to be addressed. This included a change of relevant toxicity endpoint within the 10-min to 8-h exposure time… CONTINUE READING
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