Application of phosphoinositide-binding domains for the detection and quantification of specific phosphoinositides.

@article{Furutani2006ApplicationOP,
  title={Application of phosphoinositide-binding domains for the detection and quantification of specific phosphoinositides.},
  author={Masahiro Furutani and Kazuya Tsujita and Toshiki Itoh and Takeshi Ijuin and Tadaomi Takenawa},
  journal={Analytical biochemistry},
  year={2006},
  volume={355 1},
  pages={
          8-18
        }
}
In mammals, seven phosphoinositides are known to play crucial roles as signaling molecules in a variety of cellular processes. Their synthesis and degradation are thought to be strictly controlled by metabolic enzymes such as phosphoinositide kinases and phosphatases, and their aberrant activities cause diseases. Thus, there is great interest in convenient and high-throughput measurement of such activities for the screening of drugs that enhance or block them. To date, radioactive labeling and… CONTINUE READING
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