Application of pharmacometric approaches to evaluate effect of weight and renal function on pharmacokinetics of alogliptin.

AIMS The aims of the study were to characterize the pharmacokinetics (PK) of alogliptin in healthy and type 2 diabetes mellitus (T2DM) subjects using a population PK approach and to assess the influence of various covariates on alogliptin exposure. METHODS Plasma concentration data collected from two phase 1 studies and one phase 3 study following… CONTINUE READING