Application of partial least squares discriminant analysis to two-dimensional difference gel studies in expression proteomics.

@article{Karp2005ApplicationOP,
  title={Application of partial least squares discriminant analysis to two-dimensional difference gel studies in expression proteomics.},
  author={Natasha A. Karp and Julian Leether Griffin and Kathryn S. Lilley},
  journal={Proteomics},
  year={2005},
  volume={5 1},
  pages={81-90}
}
Two-dimensional difference gel electrophoresis (DIGE) is a tool for measuring changes in protein expression between samples involving pre-electrophoretic labeling ith cyanine dyes. In multi-gel experiments, univariate statistical tests have been used to identify differential expression between sample types by looking for significant changes in spot volume. Multivariate statistical tests, which look for correlated changes between sample types, provide an alternate approach for identifying spots… CONTINUE READING

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