Application of new methodologies based on design of experiments, independent component analysis and design space for robust optimization in liquid chromatography.

@article{Debrus2011ApplicationON,
  title={Application of new methodologies based on design of experiments, independent component analysis and design space for robust optimization in liquid chromatography.},
  author={Benjamin Debrus and Pierre Lebrun and Attilio Ceccato and Gabriel Caliaro and Eric Rozet and Iolanda Nistor and Radu Nicolae Oprean and Francisco Javier Rup{\'e}rez and Coral Barbas and Bruno Boulanger and Philippe Hubert},
  journal={Analytica chimica acta},
  year={2011},
  volume={691 1-2},
  pages={33-42}
}
HPLC separations of an unknown sample mixture and a pharmaceutical formulation have been optimized using a recently developed chemometric methodology proposed by W. Dewé et al. in 2004 and improved by P. Lebrun et al. in 2008. This methodology is based on experimental designs which are used to model retention times of compounds of interest. Then, the prediction accuracy and the optimal separation robustness, including the uncertainty study, were evaluated. Finally, the design space (ICH Q8(R1… CONTINUE READING

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