Application of near-infrared spectroscopy combined with multivariate analysis in monitoring of crude heparin purification process.

Ion-exchange chromatography is a widely used purification technology in the heparin manufacturing process. To improve the efficiency and understand the process directly, a rapid and equally precise method needs to be developed to measure heparin concentration in chromatography process. Here, two robust partial least squares regression (PLS-R) models were… CONTINUE READING