Application of multivariate data analysis for identification and successful resolution of a root cause for a bioprocessing application.

@article{Kirdar2008ApplicationOM,
  title={Application of multivariate data analysis for identification and successful resolution of a root cause for a bioprocessing application.},
  author={Alime Ozlem Kirdar and Ken Green and Anurag S. Rathore},
  journal={Biotechnology progress},
  year={2008},
  volume={24 3},
  pages={720-6}
}
Multivariate Data Analysis (MVDA) can be used for supporting key activities required for successful bioprocessing. These activities include process characterization, process scale-up, process monitoring, fault diagnosis and root cause analysis. This paper examines an application of MVDA towards root cause analysis for identifying scale-up differences and parameter interactions that adversely impact cell culture process performance. Multivariate data analysis and modeling were performed using… CONTINUE READING

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