Application of melt extrusion in the development of a physically and chemically stable high-energy amorphous solid dispersion of a poorly water-soluble drug.

@article{Lakshman2008ApplicationOM,
  title={Application of melt extrusion in the development of a physically and chemically stable high-energy amorphous solid dispersion of a poorly water-soluble drug.},
  author={Jay P Lakshman and Yu Cao and James P Kowalski and Abu T M Serajuddin},
  journal={Molecular pharmaceutics},
  year={2008},
  volume={5 6},
  pages={994-1002}
}
Formulation of active pharmaceutical ingredients (API) in high-energy amorphous forms is a common strategy to enhance solubility, dissolution rate and, consequently, oral bioavailability of poorly water-soluble drugs. Amorphous APIs are, however, susceptible to recrystallization and, therefore, there is a need to physically stabilize them as solid dispersions in polymeric carriers. Hot melt extrusion has in recent years gained wide acceptance as a method of choice for the preparation of solid… CONTINUE READING

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Hot - melt extrusion technique : A review

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