Application of mass spectrometry for target identification and characterization

@article{Loo1999ApplicationOM,
  title={Application of mass spectrometry for target identification and characterization},
  author={Joseph A. Loo and Dana Dejohn and Ping Du and Tracy I. Stevenson and Rachel R. Ogorzalek Loo},
  journal={Medicinal Research Reviews},
  year={1999},
  volume={19}
}
Mass spectrometry‐based methodologies span the vast expanse of drug discovery. Both electrospray ionization (ESI) and matrix‐assisted laser desorption/ionization (MALDI) support proteomics‐based research projects by identifying proteins separated and isolated by polyacrylamide gel electrophoresis. MALDI‐MS‐based surface scanning of one‐dimensional isoelectric focusing gels, “virtual 2‐D gel electrophoresis,” represents a potentially high throughput means to map proteins and to determine protein… 

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